A three-component coupling approach to the marine bis-indole alkaloids: Topsentin, deoxytopsentin and bromotopsentin

被引：31

作者：

Achab, S

机构：

[1] Université de Reims, UFR de Pharmacie, Lab. Transformations et Synt. de S., F 51096 Reims

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 31期

关键词：

D O I：

10.1016/0040-4039(96)01148-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total syntheses of three marine his-indole alkaloids (1, 2, 4) of the topsentin family together with the synthesis of the unnatural deoxybromotopsentin (33) are described. Key elements include, a 1,2-addition-oxidation sequence to construct the bis-heteroarylketones (18, 19, 29, 30) and a Pd-catalyzed heteroarylation involving the 3-stannylindoles (12, 26) Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：5503 / 5506

页数：4

共 20 条

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