AN EXPEDITIOUS SYNTHESIS OF STRUCTURAL ANALOGS OF THE MARINE CYTOTOXIC AGENTS GROSSULARINES-1 AND GROSSULARINES-2

被引：44

作者：

ACHAB, S ^{[1
]}

GUYOT, M ^{[1
]}

POTIER, P ^{[1
]}

机构：

[1] MUSEUM NATL HIST NAT,CNRS,CHIM LAB,F-75231 PARIS 05,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 15期

关键词：

D O I：

10.1016/0040-4039(95)00323-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short access to 2-carbethoxy-3-(5-imidazolyl)indoles (13, 14, 16), featuring Pd-catalyzed cross coupling between 3-iodoindoles (10-12) and imidazolostannane (9) has been developed. These derivatives when subjected to tandem modified Curtius rearrangement-intramolecular electrocyclization led to the pyridones (19-23) which are key intermediates in the synthesis of the analogs (31), (33) and (36) of the naturally occurring cytotoxic alpha-carbolines grossularines-1 and -2 (1,2).

引用

页码：2615 / 2618

页数：4

共 27 条

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