Over the past several years, explosive new developments have occurred in both palladium and nucleoside chemistry. As such, palladium cross-coupling reactions have found many potential application in the syntheses of nucleoside analogues used in antiviral or anticancer chemotherapy. The development of solid-phase palladium-catalyzed reactions, as well as the discovery of new applications of the C-N bond formation, will be of great value in exploring new families of nucleosides.