The Inhibitory Effect on Aldose Reductase by an Extract of Ganoderma lucidum

被引：33

作者：

Fatmawati, Sri ^{[1
,2
]}

Kurashiki, Kenji ^{[1
]}

Takeno, Sayaka ^{[1
]}

Kim, Yong-ung ^{[1
]}

Shimizu, Kuniyoshi ^{[1
]}

Sato, Masao ^{[3
]}

Imaizumi, Katsumi ^{[3
]}

Takahashi, Kaori ^{[4
]}

Kamiya, Shinji ^{[4
]}

Kaneko, Shuhei ^{[5
]}

Kondo, Ryuichiro ^{[1
]}

机构：

[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Fukuoka 8128581, Japan

[2] Sepuluh Nopember Inst Technol, Fac Math & Nat Sci, Dept Chem, Surabaya 60111, Indonesia

[3] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Fukuoka 8128581, Japan

[4] TDK Akita Lab Corp, Akita 0180493, Japan

[5] Fukuoka Prefecture Forest Res & Extens Ctr, Fukuoka 8390827, Japan

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 01期

关键词：

Ganoderma lucidum; aldose reductase; diabetic complications; FRUITING BODIES; UNITED-STATES; ACCUMULATION; SORBITOL; MEDICINE; MUSCLE; POLYOL;

D O I：

10.1002/ptr.2425

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The human aldose reductase inhibitory effects of the methanol extracts of 1.7 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum (in the galactitol level in the eve lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation. Copyright (c) 2008 John Wiley & Sons, Ltd.

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页码：28 / 32

页数：5

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