Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum

被引：321

作者：

El-Mekkawy, S

Meselhy, MR

Nakamura, N

Tezuka, Y

Hattori, M

Kakiuchi, N

Shimotohno, K

Kawahata, T

Otake, T

机构：

[1] Toyama Med & Pharmaceut Univ, Res Inst Tradit Sinojapanese Med, Toyama 9300194, Japan

[2] Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068397, Japan

[3] Osaka Prefectural Inst Publ Hlth, Higashinari Ku, Osaka 5370025, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 06期

关键词：

Ganoderma lucidum; Polyporaceae; bioactive plant products; anti-HIV-1; HIV-1-protease; triterpene; ganoderiol F; ganodermanontriol;

D O I：

10.1016/S0031-9422(98)00254-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 mu g ml(-1) for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1651 / 1657

页数：7

共 33 条

[1] BABA M, 1989, J ACQ IMMUN DEF SYND, V2, P264
[2] ANTI-AIDS AGENTS .6. SALASPERMIC ACID, AN ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII, AND THE STRUCTURE-ACTIVITY CORRELATION WITH ITS RELATED-COMPOUNDS
CHEN, K
KASHIWADA, Y
ZHANG, DC
HU, CQ
JIN, JQ
NOZAKI, H
KILKUSKIE, RE
TRAMONTANO, E
CHENG, YC
MCPHAIL, DR
MCPHAIL, AT
LEE, KH
SHI, Q
[J]. JOURNAL OF NATURAL PRODUCTS, 1992, 55 (03): : 340 - 346
[3] DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF COSALANE, A NOVEL ANTI-HIV AGENT WHICH INHIBITS MULTIPLE FEATURES OF VIRUS REPRODUCTION
CUSHMAN, M
GOLEBIEWSKI, WM
MCMAHON, JB
BUCKHEIT, RW
CLANTON, DJ
WEISLOW, O
HAUGWITZ, RD
BADER, JP
GRAHAM, L
RICE, WG
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (19) : 3040 - 3050
[4] ELMEKKAWY S, 1995, CHEM PHARM BULL, V43, P641, DOI 10.1248/cpb.43.641
[5] Betulinic acid derivatives: A new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action
Evers, M
Poujade, C
Soler, F
Ribeill, Y
James, C
Lelievre, Y
Gueguen, JC
Reisdorf, D
Morize, I
Pauwels, R
DeClercq, E
Henin, Y
Bousseau, A
Mayaux, JF
LePecq, JB
Dereu, N
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (05) : 1056 - 1068
[6] MINOR AND TRACE STEROLS IN MARINE-INVERTEBRATES .26. ISOLATION AND STRUCTURE ELUCIDATION OF 9 NEW 5-ALPHA,8-ALPHA-EPIDIOXY STEROLS FROM 4 MARINE ORGANISMS
GUNATILAKA, AAL
GOPICHAND, Y
SCHMITZ, FJ
DJERASSI, C
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (19) : 3860 - 3866
[7] HANSSEN HP, 1988, DTSCH APOTH ZTG, V128, P789
[8] HE Y, 1992, J CHIN PHARM SCI, V1, P79
[9] HIKINO H, 1989, Planta Medica, V55, P423, DOI 10.1055/s-2006-962057
[10] ANTIDIABETES DRUGS .34. HYPOGLYCEMIC ACTIONS OF SOME HETEROGLYCANS OF GANODERMA-LUCIDUM FRUIT BODIES
HIKINO, H
MIZUNO, T
[J]. PLANTA MEDICA, 1989, (04) : 385 - 385

← 1 2 3 4 →