Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum

被引：321

作者：

El-Mekkawy, S

Meselhy, MR

Nakamura, N

Tezuka, Y

Hattori, M

Kakiuchi, N

Shimotohno, K

Kawahata, T

Otake, T

机构：

[1] Toyama Med & Pharmaceut Univ, Res Inst Tradit Sinojapanese Med, Toyama 9300194, Japan

[2] Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068397, Japan

[3] Osaka Prefectural Inst Publ Hlth, Higashinari Ku, Osaka 5370025, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 06期

关键词：

Ganoderma lucidum; Polyporaceae; bioactive plant products; anti-HIV-1; HIV-1-protease; triterpene; ganoderiol F; ganodermanontriol;

D O I：

10.1016/S0031-9422(98)00254-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 mu g ml(-1) for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1651 / 1657

页数：7

共 33 条

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