cDNA microarray analysis reveals the capacity of the cold-adapted Antarctic fish Trematomus bernacchii to alter gene expression in response to heat stress
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作者:
Buckley, Bradley A.
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Portland State Univ, Dept Biol, Portland, OR 97207 USAPortland State Univ, Dept Biol, Portland, OR 97207 USA
Buckley, Bradley A.
[1
]
Somero, George N.
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Stanford Univ, Hopkins Marine Stn, Pacific Grove, CA 93950 USAPortland State Univ, Dept Biol, Portland, OR 97207 USA
Somero, George N.
[2
]
机构:
[1] Portland State Univ, Dept Biol, Portland, OR 97207 USA
[2] Stanford Univ, Hopkins Marine Stn, Pacific Grove, CA 93950 USA
During their many millions of years of evolution in the extreme and stable cold, Antarctic notothenioid fishes have acquired profoundly cold-adapted physiologies. Gene expression profiling via cDNA microarray was used to determine the extent to which one species of notothenioid, Trematomus bernacchii, has retained the ability to alter gene expression in response to heat stress. While an inability to up-regulate the expression of any size class of heat shock proteins (except for a 1.1-fold induction of the co-chaperone Hsp40) was observed, hundreds of additional genes, associated with a broad range of cellular processes, were responsive to heat. Many of these genes are associated with central aspects of the evolutionarily conserved cellular stress response (CSR), which plays a pivotal role in responding to physical and chemical stresses. The inability of T. bernacchii to mount a heat shock response underscores the potential susceptibility of this species to the effects of global warming.
机构:
Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA
Buckley, BA
;
Place, SP
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Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA
Place, SP
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Hofmann, GE
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Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA
机构:
Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA
Buckley, BA
;
Place, SP
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机构:
Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA
Place, SP
;
Hofmann, GE
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Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA