A tale of two tumor targets: Topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy

被引:164
作者
Cragg, GM [1 ]
Newman, DJ [1 ]
机构
[1] NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 02期
关键词
D O I
10.1021/np030420c
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The seminal discoveries of camptothecin and Taxol by Wall and Wani are discussed in a manner that demonstrates the influence that these two compounds has had on the further development of natural product, natural product-derived, and (some) synthetic entities as potential drug leads that interact either with tubulin or with topoisomerase I. The major categories of tubulin interactive agents in terms of inhibition and promotion of tubulin polymerization are briefly discussed. Likewise, a brief discussion of topoisomerase I inhibitors is presented. Lists of tubulin interactive agents and topoisomerase I inhibitors in preclinical and clinical development are given in Tables 2 and 3, respectively. This review is not meant to be exhaustive, but does illustrate the profound impact that these two plant-derived agents have had on cancer chemotherapy.
引用
收藏
页码:232 / 244
页数:13
相关论文
共 54 条
  • [1] Total synthesis of the microtubule stabilizing antitumor agent laulimalide and some nonnatural analogues:: The power of sharpless' asymmetric epoxidation
    Ahmed, A
    Hoegenauer, EK
    Enev, VAS
    Hanbauer, M
    Kaehlig, H
    Öhler, E
    Mulzer, J
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (08) : 3026 - 3042
  • [2] Macrocyclic diterpenoids from Euphorbia semiperfoliata
    Appendino, G
    Jakupovic, S
    Tron, GC
    Jakupovic, J
    Milon, V
    Ballero, M
    [J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (06): : 749 - 756
  • [3] DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin
    Bailly, C
    Riou, JF
    Colson, P
    Houssier, C
    RodriguesPereira, E
    Prudhomme, M
    [J]. BIOCHEMISTRY, 1997, 36 (13) : 3917 - 3929
  • [4] Simplified discodermolide analogues:: Synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents
    Choy, N
    Shin, YS
    Nguyen, PQ
    Curran, DP
    Balachandran, R
    Madiraju, C
    Day, BW
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (14) : 2846 - 2864
  • [5] Ciomei M., 1997, P AM ASS CANC RES, V38
  • [6] Diazonamide A and a synthetic structural analog: Disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin
    Cruz-Monserrate, Z
    Vervoort, HC
    Bai, RL
    Newman, DJ
    Howell, SB
    Los, G
    Mullaney, JT
    Williams, MD
    Pettit, GR
    Fenical, W
    Hamel, E
    [J]. MOLECULAR PHARMACOLOGY, 2003, 63 (06) : 1273 - 1280
  • [7] Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) - Production, physico-chemical and biological properties
    Gerth, K
    Bedorf, N
    Hofle, G
    Irschik, H
    Reichenbach, H
    [J]. JOURNAL OF ANTIBIOTICS, 1996, 49 (06) : 560 - 563
  • [8] TAXOL AND TAXOTERE - DISCOVERY, CHEMISTRY, AND STRUCTURE-ACTIVITY-RELATIONSHIPS
    GUENARD, D
    GUERITTEVOEGELEIN, F
    POTIER, P
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (04) : 160 - 167
  • [9] DISCODERMOLIDE - A NEW BIOACTIVE POLYHYDROXYLATED LACTONE FROM THE MARINE SPONGE DISCODERMIA-DISSOLUTA
    GUNASEKERA, SP
    GUNASEKERA, M
    LONGLEY, RE
    SCHULTE, GK
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (16) : 4912 - 4915
  • [10] Interactions of antimitotic peptides and depsipeptides with tubulin
    Hamel, E
    [J]. BIOPOLYMERS, 2002, 66 (03) : 142 - 160