Complex interactions between skeletal muscle ryanodine receptor and dihydropyridine receptor proteins

被引:40
作者
Leong, P
MacLennan, DH
机构
[1] Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada
[2] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada
关键词
sarcoplasmic reticulum; excitation-contraction coupling;
D O I
10.1139/bcb-76-5-681
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Evidence for functional interactions between the Ca2+ release channel in the skeletal muscle sarcoplasmic reticulum (the ryanodine receptor) and the L-type Ca2+ channel in the sarcolemma (the dihydropyridine receptor), leading to excitation-contraction coupling, is reviewed and experimental systems used to identify candidate sites of interaction are outlined.
引用
收藏
页码:681 / 694
页数:14
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