pH- and Redox-Responsive Polysaccharide-Based Microcapsules with Autofluorescence for Biomedical Applications

被引：103

作者：

Gao, Liang ^{[1
]}

Fei, Jinbo ^{[1
]}

Zhao, Jie ^{[1
]}

Cui, Wei ^{[1
]}

Cui, Yue ^{[1
]}

Li, Junbai ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Ctr Mol Sci, Key Lab Colloid & Interface Sci,Inst Chem, Beijing 100190, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 11期

关键词：

autofluorescence; drug delivery; microcapsules; polysaccharide; DRUG-DELIVERY; POLYMER CAPSULES; MULTILAYER CAPSULES; CARGO RELEASE; STABILIZATION; ENCAPSULATION; MICROSPHERES; NANOCARRIERS; TEMPLATES; PARTICLES;

D O I：

10.1002/chem.201103584

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Autofluorescent microcapsules were assembled by covalent cross-linking of polysaccharide alginate dialdehyde (ADA) derivative and cystamine dihydrochloride (CM) through a layer-by-layer (LBL) technique. The formulated Schiff base and disulfide bonds render capsules with pH- and redox-responsive properties for pinpointed intracellular delivery based on the physiological difference between intracellular and extracellular environments. This simple and versatile method could be extended to other polysaccharide derivatives for the fabrication of autofluorescent nano- and micromaterials with dual stimuli response for biomedical applications.

引用

页码：3185 / 3192

页数：8

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