Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release

被引：353

作者：

Dai, Jian ^{[1
]}

Lin, Shudong ^{[1
]}

Cheng, Du ^{[1
]}

Zou, Seyin ^{[2
]}

Shuai, Xintao ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Minist Educ, PCFM Lab, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Biomed Engn, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 40期

关键词：

acidity; antitumor agents; drug delivery; micelles; reduction; POLYMERIC MICELLES; COPOLYMER MICELLES; CANCER-THERAPY; DELIVERY; SHELL; NANOPARTICLES; CARRIERS; GLYCOL);

D O I：

10.1002/anie.201103806

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On the double: A highly packed interlayer-crosslinked micelle (HP-ICM) with pH and reduction sensitivity was developed for targeted drug release (see picture; DTT=dithiothreitol, red circles=doxorubicin). The HP-ICM suppresses drug leakage in blood circulation while rapidly releasing drug inside lysosomes of cancer cells. Biological studies revealed the potential of the dual-sensitive HP-ICM in cancer treatment. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9404 / 9408

页数：5

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