Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

被引：353

作者：

Koo, Ahn Na ^{[1
]}

Lee, Hong Jae ^{[1
]}

Kim, Sung Eun ^{[1
]}

Chang, Jeong Ho ^{[1
]}

Park, Chiyoung ^{[2
]}

Kim, Chulhee ^{[2
]}

Park, Jae Hyung ^{[3
,4
]}

Lee, Sang Cheon ^{[1
]}

机构：

[1] Korea Inst Ceram Engn & Technol, Nanomat Applicat Div, Seoul 153801, South Korea

[2] Inha Univ, Dept Polymer Sci & Engn, Hyperstruct Organ Mat Res Ctr, Inchon 402751, South Korea

[3] Kyung Hee Univ, Dept Adv Polymer, Gyeonggi Do 446701, South Korea

[4] Kyung Hee Univ, Dept Nanopharmaceut Sci, Gyeonggi Do 446701, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 48期

关键词：

D O I：

10.1039/b815918a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

引用

页码：6570 / 6572

页数：3

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