Cancer stem cells, cornerstone of radioresistance and perspectives for radiosensitization: glioblastoma as an example

被引：17

作者：

Chargari, Cyrus ^{[1
,2
]}

Moncharmont, Coralie ^{[3
,4
]}

Levy, Antonin ^{[6
]}

Guy, Jean-Baptiste ^{[3
]}

Bertrand, Gerald ^{[4
]}

Guilbert, Matthieu ^{[5
]}

Rousseau, Claire ^{[1
]}

Vedrine, Lionel ^{[1
]}

Alphonse, Gersende ^{[4
]}

Toillon, Robert-Alain ^{[5
]}

Rodriguez-Lafrasse, Claire ^{[4
]}

Deutsch, Eric ^{[1
,6
]}

Magne, Nicolas ^{[3
,4
]}

机构：

[1] Hop Instruct Armees Val de Grace, Serv Oncol Radiotherapie, F-75230 Paris, France

[2] Inst Gustave Roussy, Inserm 1030, Dept Radiotherapie Mol, F-94805 Villejuif, France

[3] Inst Cancerol Lucien Neuwirth, Dept Radiotherapie, F-42271 St Priest En Jarez, France

[4] Fac Med Lyon Sud, Lab Radiobiol Cellulaire & Mol, EMR3738, F-69921 Oullins, France

[5] Univ Lille 1, INSERM, U908, IFR 147, F-59000 Villeneuve Dascq, France

[6] Inst Gustave Roussy, Dept Radiotherapie, F-94805 Villejuif, France

来源：

BULLETIN DU CANCER | 2012年 / 99卷 / 12期

关键词：

cancer stem cells; radioresistance; hypoxia; radiation therapy; SELF-RENEWAL; RADIATION-RESISTANCE; PERIVASCULAR NICHE; INITIATING CELLS; INHIBITION; AUTOPHAGY; SURVIVAL; GROWTH; DEATH;

D O I：

10.1684/bdc.2012.1666

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer stem cells are a subject of increasing interest in oncology. In particular, several data suggest that cancer stem cells are involved in the mechanisms of tumor radioresistance, and may explain the therapeutic failures after radiotherapy. Because of its poor prognosis and high recurrence rate after irradiation, glioblastoma model is often studied in the search for new radiosensitizers. There are several preclinical data suggesting that cancer stem cells could be a potential therapeutic target for improving the biological effectiveness of radiation therapy. Through the example of glioblastoma, we review the main signaling pathways involved in the mechanisms of radiation resistance of cancer stem cells and for which pharmacological targeting could potentially enhance tumor radiosensitivity.

引用

页码：1153 / 1160

页数：8

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