The development of multi-epitope vaccines: Epitope identification, vaccine design and clinical evaluation

被引：91

作者：

Sette, A

Livingston, B

McKinney, D

Appella, E

Fikes, J

Sidney, J

Newman, M

Chesnut, R

机构：

[1] Epimmune Inc, San Diego, CA 92121 USA

[2] NCI, Div Chem, Bethesda, MD 20892 USA

来源：

BIOLOGICALS | 2001年 / 29卷 / 3-4期

关键词：

epitope; vaccines; HLA; CTL; HTL; population coverage; HIV; cancer;

D O I：

10.1006/biol.2001.0297

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed efficient methods for epitope identification and vaccine design. Our process for epitope selection based on the combined use of motif analyses, binding assays and immunogenicity evaluations is described. We also describe how the projected population coverage and vaccine design can be optimized. Finally, it is discussed how vaccine potency is evaluated by immunogenicity and antigenicity assays. (C) 2001 The International Association for Biologicals.

引用

收藏

页码：271 / 276

页数：6

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