Alzheimer disease: Mechanistic understanding predicts novel therapies

被引:333
作者
Selkoe, DJ [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
关键词
D O I
10.7326/0003-4819-140-8-200404200-00047
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the last several years, Alzheimer disease researchers have come to agree that certain biochemical changes in the hippocampus and association cortices occur many years or decades before clinical symptoms. We can now describe a rough outline of the cascade of events leading to disease.
引用
收藏
页码:627 / 638
页数:12
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