共 93 条
Alzheimer disease: Mechanistic understanding predicts novel therapies
被引:333
作者:

Selkoe, DJ
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
关键词:
D O I:
10.7326/0003-4819-140-8-200404200-00047
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
In the last several years, Alzheimer disease researchers have come to agree that certain biochemical changes in the hippocampus and association cortices occur many years or decades before clinical symptoms. We can now describe a rough outline of the cascade of events leading to disease.
引用
收藏
页码:627 / 638
页数:12
相关论文
共 93 条
- [1] Inflammation and Alzheimer's disease[J]. NEUROBIOLOGY OF AGING, 2000, 21 (03) : 383 - 421Akiyama, H论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USABarger, S论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USABarnum, S论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USABradt, B论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USABauer, J论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USACole, GM论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USACooper, NR论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAEikelenboom, P论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAEmmerling, M论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAFiebich, BL论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAFinch, CE论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAFrautschy, S论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAGriffin, WST论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAHampel, H论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAHull, M论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USALandreth, G论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USALue, LF论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAMrak, R论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAMackenzie, IR论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAMcGeer, PL论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAO'Banion, MK论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAPachter, J论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAPasinetti, G论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAPlata-Salaman, C论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USARogers, J论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USARydel, R论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAShen, Y论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAStreit, W论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAStrohmeyer, R论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USATooyoma, I论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAVan Muiswinkel, FL论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAVeerhuis, R论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAWalker, D论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAWebster, S论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAWegrzyniak, B论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAWenk, G论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USAWyss-Coray, T论文数: 0 引用数: 0 h-index: 0机构: Sun Hlth Res Inst, Sun City, AZ 85372 USA Sun Hlth Res Inst, Sun City, AZ 85372 USA
- [2] Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 15233 - 15238Bales, KR论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USAVerina, T论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USACummins, DJ论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USADu, YS论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USADodel, TC论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USASaura, J论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USAFishman, CE论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USADeLong, CA论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USAPiccardo, P论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USAPetegnief, V论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USAGhetti, B论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USAPaul, SM论文数: 0 引用数: 0 h-index: 0机构: Lilly Res Labs, Indianapolis, IN 46285 USA Lilly Res Labs, Indianapolis, IN 46285 USA
- [3] Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease[J]. NATURE MEDICINE, 2000, 6 (08) : 916 - 919Bard, F论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USACannon, C论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USABarbour, R论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USABurke, RL论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAGames, D论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAGrajeda, H论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAGuido, T论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAHu, K论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAHuang, JP论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAJohnson-Wood, K论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAKhan, K论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAKholodenko, D论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USALee, M论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USALieberburg, I论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAMotter, R论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USANguyen, M论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USASoriano, F论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAVasquez, N论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAWeiss, K论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAWelch, B论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USASeubert, P论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USASchenk, D论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USAYednock, T论文数: 0 引用数: 0 h-index: 0机构: Elan Pharmaceut, S San Francisco, CA 94080 USA Elan Pharmaceut, S San Francisco, CA 94080 USA
- [4] HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY[J]. CELL, 1994, 77 (06) : 817 - 827BEHL, C论文数: 0 引用数: 0 h-index: 0机构: The Salk Institute for Biological Studies San DiegoDAVIS, JB论文数: 0 引用数: 0 h-index: 0机构: The Salk Institute for Biological Studies San DiegoLESLEY, R论文数: 0 引用数: 0 h-index: 0机构: The Salk Institute for Biological Studies San DiegoSCHUBERT, D论文数: 0 引用数: 0 h-index: 0机构: The Salk Institute for Biological Studies San Diego
- [5] Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent γ-secretase cleavage[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (32) : 30018 - 30023Berezovska, O论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USAJack, C论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USADeng, A论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USAGastineau, N论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USARebeck, GW论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USAHyman, BT论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Dis Res Lab,Alzheimers Dis Unit, Charlestown, MA 02129 USA
- [6] BACE1 is the major β-secretase for generation of Aβ peptides by neurons[J]. NATURE NEUROSCIENCE, 2001, 4 (03) : 233 - 234Cai, HB论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USAWang, YS论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USAMcCarthy, D论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USAWen, HJ论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USABorchelt, DR论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USAPrice, DL论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USAWong, PC论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
- [7] A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60[J]. SCIENCE, 2001, 293 (5527) : 115 - 120Cao, XW论文数: 0 引用数: 0 h-index: 0机构: Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dept Mol Genet, Dallas, TX 75390 USASüdhof, TC论文数: 0 引用数: 0 h-index: 0机构: Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dept Mol Genet, Dallas, TX 75390 USA
- [8] Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice[J]. NEURON, 2001, 30 (03) : 665 - 676Cherny, RA论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaAtwood, CS论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaXilinas, ME论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaGray, DN论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaJones, WD论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaMcLean, CA论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaBarnham, KJ论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaVolitakis, I论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaFraser, FW论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaKim, YS论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaHuang, XD论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaGoldstein, LE论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaMoir, RD论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaLim, JT论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaBeyreuther, K论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaZheng, H论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaTanzi, RE论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaMasters, CL论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, AustraliaBush, AI论文数: 0 引用数: 0 h-index: 0机构: Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia
- [9] beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease[J]. NEUROBIOLOGY OF AGING, 1996, 17 (06) : 921 - 933Cummings, BJ论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USA UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USAPike, CJ论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USA UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USAShankle, R论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USA UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USACotman, CW论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USA UNIV CALIF IRVINE, INST BRAIN AGING & DEMENTIA, IRVINE, CA 92717 USA
- [10] A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain[J]. NATURE, 1999, 398 (6727) : 518 - 522De Strooper, B论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, Belgium Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumAnnaert, W论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumCupers, P论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumSaftig, P论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumCraessaerts, K论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumMumm, JS论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumSchroeter, EH论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumSchrijvers, V论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumWolfe, MS论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, BelgiumRay, WJ论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven VIB, Ctr Human Genet, Neuronal Cell Biol & Gene Transfer Lab, B-3000 Louvain, Belgium论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构: