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Alzheimer disease: Mechanistic understanding predicts novel therapies

被引：333
作者：
Selkoe, DJ [1 ]
机构：
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA
来源：
ANNALS OF INTERNAL MEDICINE | 2004年 / 140卷 / 08期
关键词：
D O I：
10.7326/0003-4819-140-8-200404200-00047
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In the last several years, Alzheimer disease researchers have come to agree that certain biochemical changes in the hippocampus and association cortices occur many years or decades before clinical symptoms. We can now describe a rough outline of the cascade of events leading to disease.
引用
收藏
页码：627 / 638
页数：12
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