On the road to reading the RNA-interference code

被引：470

作者：

Siomi, Haruhiko ^{[1
]}

Siomi, Mikiko C. ^{[1
,2
]}

机构：

[1] Keio Univ, Sch Med, Dept Mol Biol, Shinjuku Ku, Tokyo 1608582, Japan

[2] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

NATURE | 2009年 / 457卷 / 7228期

关键词：

PIWI-INTERACTING RNAS; DOUBLE-STRANDED-RNA; C-ELEGANS; MESSENGER-RNA; ENDOGENOUS SIRNAS; POSTTRANSCRIPTIONAL REGULATION; MICROPROCESSOR COMPLEX; CAENORHABDITIS-ELEGANS; MICRORNA BIOGENESIS; ARGONAUTE PROTEINS;

D O I：

10.1038/nature07754

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The finding that sequence- specific gene silencing occurs in response to the presence of double- stranded RNAs has had an enormous impact on biology, uncovering an unsuspected level of regulation of gene expression. This process, known as RNA interference ( RNAi) or RNA silencing, involves small non- coding RNAs, which associate with nuclease- containing regulatory complexes and then pair with complementary messenger RNA targets, thereby preventing the expression of these mRNAs. Remarkable progress has been made towards understanding the underlying mechanisms of RNAi, raising the prospect of deciphering the 'RNAi code' that, like transcription factors, allows the fine- tuning and networking of complex suites of gene activity, thereby specifying cellular physiology and development.

引用

页码：396 / 404

页数：9

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