Target validation of G-protein coupled receptors

被引:306
作者
Wise, A [1 ]
Gearing, K [1 ]
Rees, S [1 ]
机构
[1] GlaxoSmithKline, Mol Screening Dept, Med Res Ctr, Stevenage SG1 2NY, Herts, England
关键词
D O I
10.1016/S1359-6446(01)02131-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
G-protein coupled receptors (GPCRs) represent possibly the most important target class of proteins for drug discovery. Over 30% of clinically marketed drugs are active at this receptor family. These drugs exhibit their activity at <10% of all known GPCRs. A major challenge for the pharmaceutical industry is to associate the many novel GPCRs with disease to identify the drugs of the future. This process consists of a collection of experimental paradigms that together can be loosely labelled 'target validation'.
引用
收藏
页码:235 / 246
页数:12
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