The emerging multiple roles of nuclear Akt

被引：215

作者：

Martelli, Alberto M. ^{[1
,2
]}

Tabellini, Giovanna ^{[3
]}

Bressanin, Daniela ^{[1
]}

Ognibene, Andrea ^{[4
]}

Goto, Kaoru ^{[5
]}

Cocco, Lucio ^{[1
]}

Evangelisti, Camilla ^{[2
]}

机构：

[1] Univ Bologna, Dept Biomed & Neuromotor Sci, I-40126 Bologna, Italy

[2] CNR, Rizzoli Orthoped Inst, Inst Mol Genet, I-40136 Bologna, Italy

[3] Univ Brescia, Dept Biomed Sci & Biotechnol, I-25123 Brescia, Italy

[4] Rizzoli Orthoped Inst, Lab Muscoloskeletal Cell Biol, I-40136 Bologna, Italy

[5] Yamagata Univ, Sch Med, Dept Anat & Cell Biol, Yamagata 9909585, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2012年 / 1823卷 / 12期

关键词：

Akt; Nucleus; Cell survival; Cell proliferation; Tumorigenesis; mRNA export; PROTEIN-KINASE-B; CELL-CYCLE ARREST; PHOSPHATIDYLINOSITOL 3-KINASE/AKT/MAMMALIAN TARGET; MESSENGER-RNA EXPORT; MTOR COMPLEX 1; NF-KAPPA-B; PROSTATE-CANCER; DNA FRAGMENTATION; PHOSPHOINOSITIDE; 3-KINASE; CONSTITUTIVE ACTIVATION;

D O I：

10.1016/j.bbamcr.2012.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Akt is a central player in the signal transduction pathways activated in response to many growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of cellular functions including proliferation and survival, autophagy, metabolism, angiogenesis, motility, and exocytosis. Moreover, dysregulated Akt activity is being implicated in the pathogenesis of a growing number of disorders, including cancer. Evidence accumulated over the past 15 years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways. For example, nuclear Akt counteracts apoptosis through a block of caspase-activated DNase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mRNA: messenger RNA export, DNA repair, and tumorigenesis. In this review, we shall summarize the most relevant findings about nuclear Akt and its functions. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：2168 / 2178

页数：11

共 183 条

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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation [J].