The dichotomous role of IL-2:: tolerance versus immunity

被引：63

作者：

Fehérvari, Z

Yamaguchi, T

Sakaguchi, S ^{[1
]}

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan

[2] Japan Sci & Technol Agcy, CREST, Kawaguchi 3320012, Japan

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 03期

关键词：

D O I：

10.1016/j.it.2006.01.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-2 (IL-2) is a well-known T-cell growth factor, which is traditionally implicated in the agonistic stimulation of immune responses. Recent work, however, has uncovered an unexpected function of this cytokine. In particular, IL-2 appears crucial to maintaining peripheral tolerance by supporting the survival and function of CD25(+)CD4(+) regulatory T cells. A recent study examining the role of IL-2 in the peripheral generation of regulatory T cells from apparently naive T cells has gone some way to reconciling the seemingly opposing functions of this cytokine.

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页码：109 / 111

页数：3

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