IL-2 mediates adjuvant effect of dendritic cells

被引：45

作者：

Granucci, F

Andrews, DM

Degli-Esposti, MA

Ricciardi-Castagnoli, P

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy

[2] Univ Western Australia, Queen Elizabeth II Med Ctr, Dept Microbiol, Nedlands, WA 6009, Australia

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 04期

关键词：

D O I：

10.1016/S1471-4906(02)02187-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research into the biology of dendritic cells (DCs) has shown that they play a central role in priming early and late immune responses. The recent finding that DCs produce interleukin-2 (IL-2) after microbial challenge suggests that this could be the mechanism by which DCs link innate and adaptive immunity. This hypothesis is supported also by the observation that murine cytomegalovirus, which is able to establish a persistent infection, can interfere with the ability of infected DCs to produce IL-2 and prime T cells.

引用

收藏

页码：169 / 171

页数：3

相关论文

共 12 条

[1] Infection of dendritic cells by murine cytomegalovirus induces functional paralysis [J].

Andrews, DM ;

Andoniou, CE ;

Granucci, F ;

Ricciardi-Castagnoli, P ;

Degli-Esposti, MA .

NATURE IMMUNOLOGY, 2001, 2 (11) :1077-1084

[2] Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor alpha chain gene [J].

Ascherman, DP ;

Migone, TS ;

Friedmann, MC ;

Leonard, WJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) :8704-8709

[3] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[4]

Dubois B, 1998, J IMMUNOL, V161, P2223

[5] Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes [J].

Dubois, B ;

Vanbervliet, B ;

Fayette, J ;

Massacrier, C ;

VanKooten, C ;

Briere, F ;

Banchereau, J ;

Caux, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (05) :941-951

[6] Dendritic cells directly trigger NK cell functions:: Cross-talk relevant in innate anti-tumor immune responses in vivo [J].

Fernandez, NC ;

Lozier, A ;

Flament, C ;

Ricciardi-Castagnoli, P ;

Bellet, D ;

Suter, M ;

Perricaudet, M ;

Tursz, T ;

Maraskovsky, E ;

Zitvogel, L .

NATURE MEDICINE, 1999, 5 (04) :405-411

[7]

Fukao T, 2000, EUR J IMMUNOL, V30, P1453, DOI 10.1002/(SICI)1521-4141(200005)30:5<1453::AID-IMMU1453>3.0.CO

[8]

2-W

[9] The Immunological Synapse: A Molecular Machine Controlling T Cell Activation [J].

Grakoui, Arash ;

Bromley, Shannon K. ;

Sumen, Cenk ;

Davis, Mark M. ;

Shaw, Andrey S. ;

Allen, Paul M. ;

Dustin, Michael L. .

JOURNAL OF IMMUNOLOGY, 2015, 194 (09) :221-227

[10] Inducible IL-2 production by dendritic cells revealed by global gene expression analysis [J].

Granucci, F ;

Vizzardelli, C ;

Pavelka, N ;

Feau, S ;

Persico, M ;

Virzi, E ;

Rescigno, M ;

Moro, G ;

Ricciardi-Castagnoli, P .

NATURE IMMUNOLOGY, 2001, 2 (09) :882-888