IL-2 mediates adjuvant effect of dendritic cells

被引：45

作者：

Granucci, F

Andrews, DM

Degli-Esposti, MA

Ricciardi-Castagnoli, P

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy

[2] Univ Western Australia, Queen Elizabeth II Med Ctr, Dept Microbiol, Nedlands, WA 6009, Australia

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 04期

关键词：

D O I：

10.1016/S1471-4906(02)02187-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research into the biology of dendritic cells (DCs) has shown that they play a central role in priming early and late immune responses. The recent finding that DCs produce interleukin-2 (IL-2) after microbial challenge suggests that this could be the mechanism by which DCs link innate and adaptive immunity. This hypothesis is supported also by the observation that murine cytomegalovirus, which is able to establish a persistent infection, can interfere with the ability of infected DCs to produce IL-2 and prime T cells.

引用

页码：169 / 171

页数：3