In vitro effects of recombinant chicken interferon-γ on immune cells

被引：26

作者：

Yeh, HY

Winslow, BJ

Junker, DE

Sharma, JM

机构：

[1] Univ Minnesota, Dept Vet Pathobiol, St Paul, MN 55108 USA

[2] Syntro Corp, Schering Plough Anim Hlth, San Diego, CA 92121 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1999年 / 19卷 / 06期

关键词：

D O I：

10.1089/107999099313848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We used the recombinant chicken interferon-gamma (ChIFN-gamma) to determine its in vitro effects on chicken immune cells, We found that ChIFN-beta gamma induced nitric oxide (NO) production, upregulated Ia expression on the cell surface, and inhibited the replication of Newcastle disease virus in NCSU and HD11 cells (chicken macrophage cell lines), In addition, ChIFN-gamma had an antiproliferative effect on RP9 cells, a chicken B cell line, Finally, ChIFN-gamma inhibited mitogenic proliferation of normal chicken spleen cells and induced the cells to generate NO. Inhibition of viral replication and mitogenic proliferation of normal cells were correlated with NO production. We conclude that recombinant chicken ChIFN-gamma modulates chicken immune cells.

引用

页码：687 / 691

页数：5

共 33 条

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