VEGF receptor signalling - in control of vascular function

被引：2542

作者：

Olsson, AK ^{[1
]}

Dimberg, A ^{[1
]}

Kreuger, J ^{[1
]}

Claesson-Welsh, L ^{[1
]}

机构：

[1] Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 05期

关键词：

D O I：

10.1038/nrm1911

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.

引用

页码：359 / 371

页数：13

共 139 条

[1] Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
Aase, K
von Euler, G
Li, X
Pontén, A
Thorén, P
Cao, R
Cao, Y
Olofsson, B
Gebre-Medhin, S
Pekny, M
Alitalo, K
Betsholtz, C
Eriksson, U
[J]. CIRCULATION, 2001, 104 (03) : 358 - 364
[2] Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
Abedi, H
Zachary, I
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) : 15442 - 15451
[3] Heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells -: Comparison of the effects of heparin and modified heparins
Ashikari- Hada, S
Habuchi, H
Kariya, Y
Kimata, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (36) : 31508 - 31515
[4] Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
Autiero, M
Luttun, A
Tjwa, M
Carmeliet, P
[J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (07) : 1356 - 1370
[5] Role of PIGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Autiero, M
Waltenberger, J
Communi, D
Kranz, A
Moons, L
Lambrechts, D
Kroll, J
Plaisance, S
De Mol, M
Bono, F
Kliche, S
Fellbrich, G
Ballmer-Hofer, K
Maglione, D
Mayr-Beyrle, U
Dewerchin, M
Dombrowski, S
Stanimirovic, D
Van Hummelen, P
Dehio, C
Hicklin, DJ
Persico, G
Herbert, JM
Communi, D
Shibuya, M
Collen, D
Conway, EM
Carmeliet, P
[J]. NATURE MEDICINE, 2003, 9 (07) : 936 - 943
[6] Vascular endothelial growth factor d is dispensable for development of the lymphatic system
Baldwin, ME
Halford, MA
Roufail, S
Williams, RA
Hibbs, ML
Grail, D
Kubo, H
Stacker, SA
Achen, MG
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (06) : 2441 - 2449
[7] Endothelial gaps: Time course of formation and closure in inflamed venules of rats
Baluk, P
Hirata, A
Thurston, G
Fujiwara, T
Neal, CR
Michel, CC
McDonald, DM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1997, 272 (01) : L155 - L170
[8] Regulation of vascular permeability by vascular endothelial growth factors
Bates, DO
Harper, SJ
[J]. VASCULAR PHARMACOLOGY, 2002, 39 (4-5) : 225 - 237
[9] Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis
Bazzoni, G
Dejana, E
[J]. PHYSIOLOGICAL REVIEWS, 2004, 84 (03) : 869 - 901
[10] Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia
Bellomo, D
Headrick, JP
Silins, GU
Paterson, CA
Thomas, PS
Gartside, M
Mould, A
Cahill, MM
Tonks, ID
Grimmond, SM
Townson, S
Wells, C
Little, M
Cummings, MC
Hayward, NK
Kay, GF
[J]. CIRCULATION RESEARCH, 2000, 86 (02) : E29 - E35

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