VEGF receptor signalling - in control of vascular function

被引：2542

作者：

Olsson, AK ^{[1
]}

Dimberg, A ^{[1
]}

Kreuger, J ^{[1
]}

Claesson-Welsh, L ^{[1
]}

机构：

[1] Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 05期

关键词：

D O I：

10.1038/nrm1911

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vascular endothelial growth-factor receptors (VEGFRs) regulate the cardiovascular system. VEGFR1 is required for the recruitment of haematopoietic precursors and migration of monocytes and macrophages, whereas VEGFR2 and VEGFR3 are essential for the functions of vascular endothelial and lymphendothelial cells, respectively. Recent insights have shed light onto VEGFR signal transduction and the interplay between different VEGFRs and VEGF co-receptors in development, adult physiology and disease.

引用

页码：359 / 371

页数：13

共 139 条

[21] Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
Dougher, M
Terman, BI
[J]. ONCOGENE, 1999, 18 (08) : 1619 - 1627
[22] Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
Dumont, DJ
Jussila, L
Taipale, J
Lymboussaki, A
Mustonen, T
Pajusola, K
Breitman, M
Alitalo, K
[J]. SCIENCE, 1998, 282 (5390) : 946 - 949
[23] Dvorak HF, 1999, CURR TOP MICROBIOL, V237, P97
[24] Ebos JML, 2004, MOL CANCER RES, V2, P315
[25] Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
Eliceiri, BP
Paul, R
Schwartzberg, PL
Hood, JD
Leng, J
Cheresh, DA
[J]. MOLECULAR CELL, 1999, 4 (06) : 915 - 924
[26] Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
Ferrara, N
CarverMoore, K
Chen, H
Dowd, M
Lu, L
OShea, KS
PowellBraxton, L
Hillan, KJ
Moore, MW
[J]. NATURE, 1996, 380 (6573) : 439 - 442
[27] ROLE OF THE FLT-1 RECEPTOR TYROSINE KINASE IN REGULATING THE ASSEMBLY OF VASCULAR ENDOTHELIUM
FONG, GH
ROSSANT, J
GERTSENSTEIN, M
BREITMAN, ML
[J]. NATURE, 1995, 376 (6535) : 66 - 70
[28] Fong GH, 1999, DEVELOPMENT, V126, P3015
[29] FOURNIER E, 1995, ONCOGENE, V11, P921
[30] Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor
Fuh, G
Li, B
Crowley, C
Cunningham, B
Wells, JA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (18) : 11197 - 11204

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