Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue

被引：75

作者：

Chien, Miao-Ping ^{[1
]}

Thompson, Matthew P. ^{[1
]}

Barback, Christopher V. ^{[2
]}

Ku, Ti-Hsuan ^{[1
]}

Hall, David J. ^{[2
]}

Gianneschi, Nathan C. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Radiol, Sch Med, La Jolla, CA 92093 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 26期

关键词：

nanoparticles; enzyme-responsive; in vivo probe; micelle; peptide; CELL-PENETRATING PEPTIDES; DRUG-DELIVERY; IN-VIVO; CANCER-CHEMOTHERAPY; MATRIX METALLOPROTEINASES; MICELLAR NANOPARTICLES; MOUSE MODEL; COPOLYMER; HYDROGEL; THERAPEUTICS;

D O I：

10.1002/adma.201300823

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3599 / 3604

页数：6

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