A nomenclature for ligand-gated ion channels

被引：436

作者：

Collingridge, Graham L. ^{[1
]}

Olsen, Richard W. ^{[2
]}

Peters, John ^{[3
]}

Spedding, Michael ^{[4
]}

机构：

[1] Univ Bristol, Dept Anat, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[3] Univ Dundee, Ninewells Hosp & Med Sch, Div Pathol & Neurosci, Inst Neurosci, Dundee DD1 9SY, Scotland

[4] Inst Res Servier, F-92150 Suresnes, France

来源：

NEUROPHARMACOLOGY | 2009年 / 56卷 / 01期

基金：

英国医学研究理事会;

关键词：

Ligand-gated ion channels; Nomenclature; UNION-OF-PHARMACOLOGY; GLUTAMATE RECEPTOR SUBUNIT; INTERNATIONAL-UNION; MOLECULAR RELATIONSHIPS; POTASSIUM CHANNELS; NMDA RECEPTOR; CLONING; GENES; CLASSIFICATION; EXPRESSION;

D O I：

10.1016/j.neuropharm.2008.06.063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine(3) (5-HT3), gamma-aminobutyric acid(A) (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely. to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2 / 5

页数：4

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