Carbamate linkers as latent N-methylamines in solid phase synthesis

被引：39

作者：

Ho, CY

Kukla, MJ

机构：

[1] Chemistry Department, Janssen Research Foundation, Spring House

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(97)00510-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new linker strategy for solid phase synthesis has been developed. It utilizes LAH reduction of a carbamate connection to Wang resin which results in N-methylamines, a useful functionality in medicinal chemistry. (C) 1997 Elsevier Science Ltd.

引用

页码：2799 / 2802

页数：4

共 13 条

[1] CHENERA B, 1995, J AM CHEM SOC, V117, P11999
[2] DIXIT DM, 1977, J CHEM SOC CHEM COMM, P798, DOI 10.1039/c39770000798
[3] Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization cleavage step
Dressman, BA
Spangle, LA
Kaldor, SW
[J]. TETRAHEDRON LETTERS, 1996, 37 (07) : 937 - 940
[4] Felix A M, 1970, J Am Chem Soc, V92, P1385, DOI 10.1021/ja00708a046
[5] Organic chemistry on solid supports
Fruchtel, JS
Jung, G
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (01): : 17 - 42
[6] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS
GORDON, EM
BARRETT, RW
DOWER, WJ
FODOR, SPA
GALLOP, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) : 1385 - 1401
[7] GORDON EM, 1994, J MED CHEM, V37, P1223
[8] A SOLID-PHASE CBZ CHLORIDE EQUIVALENT - A NEW MATRIX SPECIFIC LINKER
HAUSKE, JR
DORFF, P
[J]. TETRAHEDRON LETTERS, 1995, 36 (10) : 1589 - 1592
[9] HEMKENS PHH, 1996, TETRAHEDRON, V52, P4527
[10] REACTIONS ON POLYMER SUPPORTS
LETSINGER, RL
KORNET, MJ
MAHADEVAN, V
JERINA, DM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (23) : 5163 - &

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