Electrically controlled drug delivery from biotin-doped conductive polypyrrole

被引：249

作者：

George, PM

LaVan, DA

Burdick, JA

Chen, CY

Liang, E

Langer, R

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Yale Univ, Dept Mech Engn, New Haven, CT 06520 USA

[4] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 05期

关键词：

D O I：

10.1002/adma.200501242

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A platform for controlled drug delivery using a conductive-polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an applied potential can trigger release of the drug from the polymer surface (see figure).

引用

页码：577 / +

页数：6

共 33 条

[1] Bronfman FC, 2003, J NEUROSCI, V23, P3209
[2] A biotinylated conducting polypyrrole for the spatially controlled construction of an amperometric biosensor
Cosnier, S
Stoytcheva, M
Senillou, A
Perrot, H
Furriel, RPM
Leone, FA
[J]. ANALYTICAL CHEMISTRY, 1999, 71 (17) : 3692 - 3697
[3] Biomolecule immobilization on electrode surfaces by entrapment or attachment to electrochemically polymerized films. A review
Cosnier, S
[J]. BIOSENSORS & BIOELECTRONICS, 1999, 14 (05) : 443 - 456
[4] Reduction of cortical TrkA but not p75NTR protein in early-stage Alzheimer's disease
Counts, SE
Nadeem, M
Wuu, J
Ginsberg, SD
Saragovi, HU
Mufson, EJ
[J]. ANNALS OF NEUROLOGY, 2004, 56 (04) : 520 - 531
[5] Electrochemical deposition and characterization of conducting polymer polypyrrole/PSS on multichannel neural probes
Cui, XY
Hetke, JF
Wiler, JA
Anderson, DJ
Martin, DC
[J]. SENSORS AND ACTUATORS A-PHYSICAL, 2001, 93 (01) : 8 - 18
[6] Electrochemically controlled transport of metal ions across polypyrrole membranes using a flow-through cell
Davey, JM
Ralph, SF
Too, CO
Wallace, GG
Partridge, AC
[J]. REACTIVE & FUNCTIONAL POLYMERS, 2001, 49 (02) : 87 - 98
[7] Biotin/avidin system for the generation of fully renewable DNA sensor based on biotinylated polypyrrole film
Dupont-Filliard, A
Billon, M
Livache, T
Guillerez, S
[J]. ANALYTICA CHIMICA ACTA, 2004, 515 (02) : 271 - 277
[8] Reversible oligonucleotide immobilisation based on biotinylated polypyrrole film
Dupont-Filliard, A
Roget, A
Livache, T
Billon, M
[J]. ANALYTICA CHIMICA ACTA, 2001, 449 (1-2) : 45 - 50
[9] Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics
George, PM
Lyckman, AW
LaVan, DA
Hegde, A
Leung, Y
Avasare, R
Testa, C
Alexander, PM
Langer, R
Sur, M
[J]. BIOMATERIALS, 2005, 26 (17) : 3511 - 3519
[10] Electronic MEMS for triggered delivery
Grayson, ACR
Shawgo, RS
Li, YW
Cima, MJ
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (02) : 173 - 184

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