Electrically controlled drug delivery from biotin-doped conductive polypyrrole

被引：249

作者：

George, PM

LaVan, DA

Burdick, JA

Chen, CY

Liang, E

Langer, R

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Yale Univ, Dept Mech Engn, New Haven, CT 06520 USA

[4] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 05期

关键词：

D O I：

10.1002/adma.200501242

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A platform for controlled drug delivery using a conductive-polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an applied potential can trigger release of the drug from the polymer surface (see figure).

引用

页码：577 / +

页数：6

共 33 条

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