Comparison of Haemophilus influenzae type b interaction with respiratory mucosa organ cultures maintained with an air interface or immersed in medium

被引：12

作者：

Jackson, AD ^{[1
]}

Cole, PJ ^{[1
]}

Wilson, R ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, NATL HEART & LUNG INST, HOST DEF UNIT, LONDON, ENGLAND

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.64.6.2353-2355.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Haemophilus influenzae type b infection of immersed and air interface organ cultures for 24 h caused significant epithelial damage. Bacterial association with mucus, damaged epithelium, and unciliated cells was significantly higher in air interface than immersed organ cultures, and total bacterial association was 55.8 times greater. Bacteria exhibited tropism for mucus only on explants maintained with an air interface. We conclude that immersion of nasopharyngeal tissue in medium may influence bacterial interaction with the mucosal surface.

引用

收藏

页码：2353 / 2355

页数：3

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