Mesyl guaiacol: a versatile intermediate for the synthesis of 5-aminomethyl guaiacol and related compounds

被引：9

作者：

Bensel, N

Pevere, V

Desmurs, JR

Wagner, A

Mioskowski, C

机构：

[1] Univ Strasbourg 1, CNRS, UMR 7514, Lab Synth Bioorgan,Fac Pharm, F-67401 Illkirch Graffenstaden, France

[2] Rhodia Chim, CRIT Carriere, F-69192 St Fons, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(02)00673-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An original synthetic pathway for the preparation of 5-substituted guaiacol derivatives is described. This method relies on the deactivation of the phenol group by converting it into the corresponding mesyl ester. Amidomethylation reactions lead to regioselective C-C bond formation at the 5-position of guaiacol. Thus, 5-aminomethyl-guaiacol was obtained in four steps and 75% overall yield. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：4281 / 4283

页数：3

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