Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

被引：81

作者：

Alves, Luiz Anastacio ^{[1
]}

Soares Bezerra, Romulo Jose ^{[1
]}

Faria, Robson Xavier ^{[1
]}

Braga Ferreira, Leonardo Gomes ^{[1
]}

Frutuoso, Valber da Silva ^{[2
]}

机构：

[1] Fundacao Oswaldo Cruz, Lab Cellular Commun, Rio De Janeiro, Brazil

[2] Fundacao Oswaldo Cruz, Lab Immnopharmacol, Rio De Janeiro, Brazil

来源：

MOLECULES | 2013年 / 18卷 / 09期

关键词：

P2X7R; inflammatory response; antagonists and pharmacological target; P2X(7) PURINERGIC RECEPTOR; PHARMACOLOGICAL CHARACTERIZATION; CENTRAL SENSITIZATION; RHEUMATOID-ARTHRITIS; NUCLEOTIDE RECEPTOR; NATURAL-PRODUCTS; NEUROPATHIC PAIN; CATION CHANNELS; IN-VITRO; ATP;

D O I：

10.3390/molecules180910953

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP and triggers the secretion of several proinflammatory substances, such as IL-1 beta, IL-18, TNF-alpha, and nitric oxide. Recently, several preclinical studies have demonstrated that this receptor participates in inflammation and pain mechanisms. Taken together, these results indicate that P2X7R is a promising pharmacological target, and compounds that modulate the function of this receptor show potential as new anti-inflammatory medicines. In this review, we discuss aspects of P2X7R pharmacology and the participation of this protein in inflammation and pain and provide an overview of some promising compounds that have been tested as antagonists of P2X7R, with clinical applicability.

引用

页码：10953 / 10972

页数：20

共 125 条

[81] P2x7-related modulation of pathological nociception in rats [J].

McGaraughty, S. ;

Chu, K. L. ;

Namovic, M. T. ;

Donnelly-Roberts, D. L. ;

Harris, R. R. ;

Zhang, X.-F. ;

Shieh, C.-C. ;

Wismer, C. T. ;

Zhu, C. Z. ;

Gauvin, D. M. ;

Fabiyi, A. C. ;

Honore, P. ;

Gregg, R. J. ;

Kort, M. E. ;

Nelson, D. W. ;

Carroll, W. A. ;

Marsh, K. ;

Faltynek, C. R. ;

Jarvis, M. F. .

NEUROSCIENCE, 2007, 146 (04) :1817-1828

[82] ATP-stimulated release of interleukin (IL)-1β and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage [J].

Mehta, VB ;

Hart, J ;

Wewers, MD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (06) :3820-3826

[83] Ionic effects on human recombinant P2X7 receptor function [J].

Michel, AD ;

Chessell, IP ;

Humphrey, PPA .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1999, 359 (02) :102-109

[84] The induction of pain: An integrative review [J].

Millan, MJ .

PROGRESS IN NEUROBIOLOGY, 1999, 57 (01) :1-164

[85] In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain [J].

Mingam, Rozenn ;

De Smedt, Veronique ;

Amedee, Thierry ;

Bluthe, Rose-Marie ;

Kelley, Keith W. ;

Dantzer, Robert ;

Laye, Sophie .

BRAIN BEHAVIOR AND IMMUNITY, 2008, 22 (02) :234-244

[86] Immune and inflammatory mechanisms in neuropathic pain [J].

Moalem, Gila ;

Tracey, David J. .

BRAIN RESEARCH REVIEWS, 2006, 51 (02) :240-264

[87] A Potential Role for P2X7R in Allergic Airway Inflammation in Mice and Humans [J].

Mueller, Tobias ;

Vieira, Rodolfo Paula ;

Grimm, Melanie ;

Duerk, Thorsten ;

Cicko, Sanja ;

Zeiser, Robert ;

Jakob, Thilo ;

Martin, Stefan F. ;

Blumenthal, Britta ;

Sorichter, Stephan ;

Ferrari, Davide ;

Di Virgillio, Francesco ;

Idzko, Marco .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 44 (04) :456-464

[88]

MURGIA M, 1993, J BIOL CHEM, V268, P8199

[89] P2X Receptors as Drug Targets [J].

North, R. Alan ;

Jarvis, Michael F. .

MOLECULAR PHARMACOLOGY, 2013, 83 (04) :759-769

[90] Molecular physiology of P2X receptors [J].

North, RA .

PHYSIOLOGICAL REVIEWS, 2002, 82 (04) :1013-1067

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