Micropeptins 478-A and -B, plasmin inhibitors from the cyanobacterium Microcystis aeruginosa

被引：45

作者：

Ishida, K ^{[1
]}

Matsuda, H ^{[1
]}

Murakami, M ^{[1
]}

Yamaguchi, K ^{[1
]}

机构：

[1] UNIV TOKYO,GRAD SCH AGR & LIFE SCI,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 02期

关键词：

D O I：

10.1021/np9606815

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Micropeptins 478-A and -B, plasmin inhibitors, were isolated from the cultured cyanobacterium Microcystis aeruginosa (NIES-478). Their structures were elucidated to be 1 and 2 on the basis of 2D NMR data and chemical degradation. These cyclic depsipeptides inhibited plasmin potently with IC50 Of 0.1 and 0.4 mu g/mL, respectively.

引用

页码：184 / 187

页数：4

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