Clinical evaluation of a single oral dose of human-bovine (UK) reassortant rotavirus vaccines Wa x UK (P1A[8],G6) and Wa x (DS-1 x UK) (P1A[8],G2)

被引：13

作者：

Eichelberger, MC

Sperber, E

Wagner, M

Hoshino, Y

Dudas, R

Hodgins, V

Marron, J

Nehring, P

Casey, R

Burns, B

Karron, R

Clements-Mann, ML

Kapikian, AZ

机构：

[1] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Sch Publ Hlth, Dept Int Hlth, Ctr Immunizat Res, Baltimore, MD USA

来源：

JOURNAL OF MEDICAL VIROLOGY | 2002年 / 66卷 / 03期

关键词：

rotavirus; clinical trials; vaccine;

D O I：

10.1002/jmv.2160

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The safety, infectivity, and immunogenicity of two human-bovine reassortant rotavirus candidate vaccines were evaluated in adults, children, and infants. One of these, Wa x UK, contained a single human rotavirus gene from the Wa strain that encoded VP4 P1A specificity in a background of 10 bovine genes including the VP7 gene that encodes G6 specificity, whereas the other, Wa x (DS-1 x UK), possessed the human rotavirus VP4 gene from the Wa strain as well as the human VP7 gene from strain DS-1 that encoded G2 specificity. Each of these vaccines appeared to be well-tolerated and immunogenic in infants less than 6 months of age following a single oral dose, and therefore should be evaluated further as vaccine candidates. (C) 2002 Wiley-Liss, Inc.

引用

页码：407 / 416

页数：10