Innate sensing of bacterial cyclic dinucleotides: more than just STING

被引：24

作者：

Bowie, Andrew G. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Trin Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 12期

关键词：

DI-GMP;

D O I：

10.1038/ni.2469

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial cyclic dinucleotides are recognized by the innate immune system, and this leads to the induction of type I interferons. The mammalian helicase DDX41 directly binds cyclic dinucleotides and mediates the signaling pathway to the induction of type I interferons.

引用

页码：1137 / 1139

页数：4

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