Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

被引：313

作者：

Okano, Hideyuki ^{[1
]}

Nakamura, Masaya ^{[2
]}

Yoshida, Kenji ^{[1
,3
,6
]}

Okada, Yohei ^{[1
,3
]}

Tsuji, Osahiko ^{[1
,2
]}

Nori, Satoshi ^{[1
,2
]}

Ikeda, Eiji ^{[4
]}

Yamanaka, Shinya ^{[5
]}

Miura, Kyoko ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Physiol, Tokyo 1608582, Japan

[2] Keio Univ, Sch Med, Dept Orthoped Surg, Tokyo 1608582, Japan

[3] Keio Univ, Sch Med, Kanrinmaru Project, Tokyo 1608582, Japan

[4] Yamaguchi Univ, Grad Sch Med, Dept Pathol, Yamaguchi, Japan

[5] Kyoto Univ, Ctr iPS Cell Res & Applicat, Kyoto, Japan

[6] Dainippon Sumitomo Pharma, Genom Sci Lab, Osaka, Japan

来源：

CIRCULATION RESEARCH | 2013年 / 112卷 / 03期

关键词：

induced pluripotent stem cell; neural stem/progenitor cell; transplantation; spinal cord injury; HUMAN SOMATIC-CELLS; SPINAL-CORD-INJURY; FUNCTIONAL RECOVERY; SENDAI-VIRUS; HUMAN FIBROBLASTS; IN-VIVO; MOUSE; GENERATION; DIFFERENTIATION; CARDIOMYOCYTES;

D O I：

10.1161/CIRCRESAHA.111.256149

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The enthusiasm for producing patient-specific human embryonic stem cells using somatic nuclear transfer has somewhat abated in recent years because of ethical, technical, and political concerns. However, the interest in generating induced pluripotent stem cells (iPSCs), in which pluripotency can be obtained by transcription factor transduction of various somatic cells, has rapidly increased. Human iPSCs are anticipated to open enormous opportunities in the biomedical sciences in terms of cell therapies for regenerative medicine and stem cell modeling of human disease. On the other hand, recent reports have emphasized the pitfalls of iPSC technology, including the potential for genetic and epigenetic abnormalities, tumorigenicity, and immunogenicity of transplanted cells. These constitute serious safety-related concerns for iPSC-based cell therapy. However, preclinical data supporting the safety and efficacy of iPSCs are also accumulating. In this Review, recent achievements and future tasks for safe iPSC-based cell therapy are summarized, using regenerative medicine for repair strategies in the damaged central nervous system (CNS) as a model. Insights on safety and preclinical use of iPSCs in cardiovascular repair model are also discussed. (Circ Res. 2013;112:523-533.)

引用

页码：523 / 533

页数：11

共 87 条

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