A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents

被引：404

作者：

Jiang, HL ^{[1
]}

Hu, YQ

Li, Y

Zhao, PC

Zhu, KJ

Chen, WL

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

[2] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2005年 / 108卷 / 2-3期

基金：

中国国家自然科学基金;

关键词：

electrospinning; controlled release; core-shell;

D O I：

10.1016/j.jconrel.2005.08.006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-step, mild procedure based on coaxial electrospinning was developed for incorporation and controlled release of two model proteins, BSA and lysozyme, from biodegradable core-shell nanofibers with PCL as shell and protein-containing PEG as core. The thickness of the core and shell could be adjusted by the feed rate of the inner dope, which in turn affected the release profiles of the incorporated proteins. It was revealed that the released lysozyme maintained its structure and bioactivity. The current method may find wide applications for controlled release of proteins and tissue engineering. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：237 / 243

页数：7

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