A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells

被引：21

作者：

Cho, Tae-Jun ^{[1
,2
]}

Kim, Jonghoon ^{[3
]}

Kwon, Soon-Keun ^{[1
,2
]}

Oh, Keunhee ^{[4
]}

Lee, Jeong-ae ^{[5
]}

Lee, Dong-Sup ^{[4
]}

Cho, Jaejin ^{[1
,2
]}

Park, Seung Bum ^{[3
,5
]}

机构：

[1] Seoul Natl Univ, Sch Dent, Seoul, South Korea

[2] Seoul Natl Univ, Dent Res Inst, Seoul, South Korea

[3] Seoul Natl Univ, Dept Chem, Seoul, South Korea

[4] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea

[5] Seoul Natl Univ, Dept Biophys & Chem Biol, BioMAX Inst, Seoul 151747, South Korea

来源：

CHEMICAL SCIENCE | 2012年 / 3卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

TGF-BETA; PROGENITOR CELLS; CARTILAGE; METASTASIS; MODULATORS; CARCINOMA; ADULT;

D O I：

10.1039/c2sc20362f

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We discovered a novel small-molecule modulator 5{i,2} that can specifically induce the chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Based on our biochemical and histological studies, 5{i,2} showed more of a directed differentiation of MSCs to chondrocyte balls compared to TGF-beta 3.

引用

页码：3071 / 3075

页数：5

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