HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics

被引：115

作者：

Abecasis, Ana B. ^{[1
,2
]}

Wensing, Annemarie M. J. ^{[3
]}

Paraskevis, Dimitris ^{[4
]}

Vercauteren, Jurgen ^{[5
,6
]}

Theys, Kristof ^{[5
]}

de Vijver, David A. M. C. Van ^{[7
]}

Albert, Jan ^{[8
,9
]}

Asjo, Birgitta ^{[10
]}

Balotta, Claudia ^{[11
]}

Beshkov, Danail ^{[12
]}

Camacho, Ricardo J. ^{[2
,13
]}

Clotet, Bonaventura ^{[14
,15
]}

De Gascun, Cillian ^{[16
]}

Griskevicius, Algis ^{[17
]}

Grossman, Zehava ^{[18
,19
]}

Hamouda, Osamah ^{[20
]}

Horban, Andrzej ^{[21
,22
]}

Kolupajeva, Tatjana ^{[23
]}

Korn, Klaus ^{[24
]}

Kostrikis, Leon G. ^{[25
]}

Kuecherer, Claudia ^{[20
]}

Liitsola, Kirsi ^{[26
]}

Linka, Marek ^{[27
]}

Nielsen, Claus ^{[28
]}

Otelea, Dan ^{[29
]}

Paredes, Roger ^{[14
,15
]}

Poljak, Mario ^{[30
]}

Puchhammer-Stoeckl, Elisabeth ^{[31
]}

Schmit, Jean-Claude ^{[32
,33
]}

Sonnerborg, Anders ^{[34
,35
]}

Stanekova, Danika ^{[36
]}

Stanojevic, Maja ^{[37
]}

Struck, Daniel ^{[32
]}

Boucher, Charles A. B. ^{[7
]}

Vandamme, Anne-Mieke ^{[2
,5
]}

机构：

[1] Univ Nova Lisboa, Unidade Saude Publ Int & Bioestat, Inst Higiene & Med Trop, P-1200 Lisbon, Portugal

[2] Univ Nova Lisboa, Ctr Malaria & Outras Doencas Trop, Inst Higiene & Med Trop, P-1200 Lisbon, Portugal

[3] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[4] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[5] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

[6] Univ Antwerp, StatUa Ctr Stat, B-2020 Antwerp, Belgium

[7] Erasmus MC, Dept Virol, Rotterdam, Netherlands

[8] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[9] Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden

[10] Univ Bergen, Gade Inst, Microbiol & Immunol Sect, Bergen, Norway

[11] Univ Milan, Milan, Italy

[12] Natl Ctr Infect & Parasit Dis, Dept Virol, Sofia, Bulgaria

[13] Ctr Hosp Lisboa Ocidental, Hosp Egas Moniz, Lisbon, Portugal

[14] Hosp Univ Germans Tria Si Pujol, IrsiCaixa AIDS Res Inst, Badalona, Spain

[15] Hosp Univ Germans Tria Si Pujol, Lluita SIDA Fdn, Badalona, Spain

[16] Univ Coll Dublin, Dublin 2, Ireland

[17] Natl Publ Hlth Surveillance Lab, Vilnius, Lithuania

[18] Chaim Sheba Med Ctr, Ramat Gan, Israel

[19] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[20] Robert Koch Inst, Berlin, Germany

[21] Warsaw Med Univ, Warsaw, Poland

[22] Hosp Infect Dis, Warsaw, Poland

[23] Infectol Ctr Latvia, Riga, Latvia

[24] Univ Erlangen Nurnberg, Inst Klin & Mol Virol, Erlangen, Germany

[25] Univ Cyprus, Nicosia, Cyprus

[26] Natl Inst Hlth & Welf, Helsinki, Finland

[27] Natl Inst Publ Hlth, Prague, Czech Republic

[28] Statens Serum Inst, DK-2300 Copenhagen, Denmark

[29] Prof Dr Matei Bals Inst Infect Dis, Bucharest, Romania

[30] Univ Ljubljana, Ljubljana, Slovenia

[31] Med Univ Vienna, Vienna, Austria

[32] CRP Sante, Lab Retrovirol, Luxembourg, Luxembourg

[33] Ctr Hosp Luxembourg, Luxembourg, Luxembourg

[34] Karolinska Inst, Div Infect Dis, Stockholm, Sweden

[35] Karolinska Inst, Div Clin Virol, Stockholm, Sweden

[36] Slovak Med Univ, Bratislava, Slovakia

[37] Univ Belgrade, Sch Med, Belgrade, Serbia

来源：

RETROVIROLOGY | 2013年 / 10卷

基金：

瑞典研究理事会;

关键词：

PNEUMOCYSTIS-CARINII-PNEUMONIA; PROTEASE INHIBITORS; DISEASE PROGRESSION; RESISTANCE; MUTATION; TRANSMISSION; PREVALENCE; THERAPY; DIVERSITY; INFECTION;

D O I：

10.1186/1742-4690-10-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes. Results: We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct subtypes were found between European countries: the lowest proportion of subtype B was found in Israel (27.9%) and Portugal (39.2%), while the highest was observed in Poland (96.2%) and Slovenia (93.6%). Other subtypes were significantly more diagnosed in immigrant populations. Subtype B was significantly more diagnosed in men than in women and in MSM > IDUs > heterosexuals. Furthermore, the subtype distribution according to continent of origin of the patients suggests they acquired their infection there or in Europe from compatriots. Conclusions: The association of subtype with demographic parameters suggests highly compartmentalized epidemics, determined by social and behavioural characteristics of the patients.

引用

页数：13

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