The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: Cousins, siblings or twins?

被引：139

作者：

Brandau, Sven ^{[1
]}

Moses, Katrin ^{[1
]}

Lang, Stephan ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Dept Otorhinolaryngol, D-45122 Essen, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2013年 / 23卷 / 03期

关键词：

Neutrophils; Myeloid-derived suppressor cells; Myeloid cells; Invasion; Angiogenesis; Metastasis; Immune suppression; Cancer; Cancer patients; Tumor progression; Inflammation; Microbiota; TIMP-FREE MMP-9; TUMOR ANGIOGENESIS; T-CELLS; POLYMORPHONUCLEAR LEUKOCYTES; HEPATOCELLULAR-CARCINOMA; SELECTIN EXPRESSION; ANTITUMOR IMMUNITY; PERIPHERAL-BLOOD; LUNG METASTASIS; MOUSE MODEL;

D O I：

10.1016/j.semcancer.2013.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Neutrophils in the tumor host may promote tumor progression by enhancing angiogenesis, invasion and metastasis. Granulocytic myeloid-derived suppressor cells (MDSC) share many features with neutrophils. Classically, MDSC are viewed as and defined as immunosuppressive cells. In this article we summarize and critically review evidence for a role of MDSC in promoting angiogenesis, invasion and metastasis of solid tumors. We also attempt to provide a critical evaluation of the relationship between neutrophils and G-MDSC in the tumor host with a particular focus on human cancer. (C) 2013 Elsevier Ltd. All rights reserved.

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页码：171 / 182

页数：12

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