Sex differences in sensorimotor gating of the human startle reflex: all smoke?

被引：60

作者：

Swerdlow, NR ^{[1
]}

Geyer, MA ^{[1
]}

Hartman, PL ^{[1
]}

Sprock, J ^{[1
]}

Auerbach, PP ^{[1
]}

Cadenhead, K ^{[1
]}

Perry, W ^{[1
]}

Braff, DL ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA

来源：

PSYCHOPHARMACOLOGY | 1999年 / 146卷 / 02期

关键词：

nicotine; prepulse inhibition; schizophrenia; sensorimotor gating; startle;

D O I：

10.1007/s002130051111

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rationale: A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. Objective: To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI, rather than simple sex differences in the regulation of PPI. A retrospective analyses of >600 carefully screened normals tested over the past 12 years was completed. Results: Male>female acoustic PPI was detected in analyses that included: 1) all subjects; or 2) self-declared non-smokers. Conclusions. Sex differences in PPI cannot be accounted for by smoking history, because they are present across a large sample of non-smoking normal controls.

引用

页码：228 / 232

页数：5

共 31 条

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