Neural Correlates of Eye Gaze Processing in the Infant Broader Autism Phenotype

被引：146

作者：

Elsabbagh, Mayada ^{[1
]}

Volein, Agnes ^{[1
]}

Csibra, Gergely ^{[1
]}

Holmboe, Karla ^{[1
]}

Garwood, Holly ^{[1
]}

Tucker, Leslie ^{[1
]}

Krljes, Sanya ^{[1
]}

Baron-Cohen, Simon ^{[4
]}

Bolton, Patrick ^{[5
]}

Charman, Tony ^{[6
]}

Baird, Gillian ^{[2
]}

Johnson, Mark H. ^{[3
]}

机构：

[1] Univ London, Ctr Brain & Cognit Dev, London WC1E 7HX, England

[2] Univ London, Guys & St Thomas NHS Trust, London WC1E 7HX, England

[3] Univ London, Ctr Brain & Cognit Birkbeck, London WC1E 7HX, England

[4] Univ Cambridge, Autism Res Ctr, Cambridge CB2 1TN, England

[5] Kings Coll London, Inst Psychiat, London WC2R 2LS, England

[6] Inst Child Hlth, London, England

来源：

BIOLOGICAL PSYCHIATRY | 2009年 / 65卷 / 01期

基金：

英国医学研究理事会;

关键词：

Autism; broader autism phenotype; event-related potential; eye gaze processing; infancy; SPECTRUM DISORDER; SOCIAL-PERCEPTION; JOINT ATTENTION; YOUNG-CHILDREN; ELECTROPHYSIOLOGICAL EVIDENCE; COMMUNICATION DEVELOPMENT; OSCILLATORY ACTIVITY; GAMMA-OSCILLATIONS; ASPERGER-SYNDROME; 1ST YEAR;

D O I：

10.1016/j.biopsych.2008.09.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Studies of infant siblings of children diagnosed with autism have allowed for a prospective approach to study the emergence of autism in infancy and revealed early behavioral characteristics of the broader autism phenotype. In view of previous findings of atypical eye gaze processing in children and adults with autism, the aim of this study was to examine the early autism phenotype in infant siblings of children diagnosed with autism spectrum disorder (sib-ASD), focusing on the neural correlates of direct compared with averted gaze. Methods: A group of 19 sib-ASD was compared with 17 control infants with no family history of ASD (mean age = 10 months) on their response to direct versus averted gaze in static stimuli. Results: Relative to the control group, the sib-ASD group showed prolonged latency of the occipital P400 event-related potentials component in response to direct gaze, but they did not differ in earlier components. Similarly, time-frequency analysis of high-frequency oscillatory activity in the gamma band showed group differences in response to direct gaze, where induced gamma activity was late and less persistent over the right temporal region in the sib-ASD group. Conclusion: This study suggests that a broader autism phenotype, which includes an atypical response to direct gaze, is manifest early in infancy.

引用

页码：31 / 38

页数：8

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