Parallel progression of primary tumours and metastases

被引：861

作者：

Klein, Christoph A. ^{[1
]}

机构：

[1] Univ Regensburg, Div Oncogen, Dept Pathol, D-93053 Regensburg, Germany

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 04期

关键词：

COMPARATIVE GENOMIC HYBRIDIZATION; BREAST-CANCER METASTASIS; BONE-MARROW; GENETIC-HETEROGENEITY; ADJUVANT CHEMOTHERAPY; BRAIN METASTASES; NATURAL-HISTORY; PROSTATE-CANCER; GROWTH-FACTOR; LUNG-CANCER;

D O I：

10.1038/nrc2627

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Systemic cancer progression is accounted for in two basic models. The prevailing archetype places the engine of cancer progression within the primary tumour before metastatic dissemination of fully malignant cells. The second posits parallel, independent progression of metastases arising from early disseminated tumour cells. This Perspective draws together data from disease courses, tumour growth rates, autopsy studies, clinical trials and molecular genetic analyses of primary and disseminated tumour cells in support of the parallel progression model. consideration of this model urges review of current diagnostic and therapeutic routines.

引用

页码：302 / 312

页数：12

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