Organocatalytic direct asymmetric α-heteroatom functionalization of aldehydes and ketones

被引：327

作者：

Marigo, M ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Catalysis, Danish Natl Res Fdn, DK-8000 Aarhus C, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 19期

关键词：

D O I：

10.1039/b517090g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct enantioselective introduction of a stereogenic carbon-heteroatom bond adjacent to a carbonyl functionality leads to optically active compounds of significant importance for e.g. the life-science industry. Organocatalytic enantioselective amination, oxygenation, fluorination, chlorination, bromination and sulfenylation of aldehydes and ketones, using chiral amines as the catalysts, are reviewed in this feature article. Furthermore, a few other transformations are also outlined. The scope, potential and application of these organocatalytic asymmetric reactions are presented and the mechanistic aspects discussed.

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页码：2001 / 2011

页数：11

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