Diagnostic and Prognostic Microbial Biomarkers in Inflammatory Bowel Diseases

被引：65

作者：

Dubinsky, Marla ^{[1
]}

Braun, Jonathan ^{[2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Div Pediat Gastroenterol & Hepatol, Dept Pediat, New York, NY 10029 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

GASTROENTEROLOGY | 2015年 / 149卷 / 05期

关键词：

Gastrointestinal Disease; Genetics; Genomics; Immunology; ANTI-SACCHAROMYCES-CEREVISIAE; POUCH-ANAL ANASTOMOSIS; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; COMPLICATED CROHNS-DISEASE; INCREASED INTESTINAL PERMEABILITY; BIOSYNTHETIC GENE CLUSTERS; INDETERMINATE COLITIS; ULCERATIVE-COLITIS; SEROLOGICAL MARKERS; HUMAN GUT;

D O I：

10.1053/j.gastro.2015.08.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The microbiome plays multifaceted roles in the pathogenesis of inflammatory bowel diseases (IBD). Accordingly, the clinical challenge of patient heterogeneity in disease phenotype and response to treatment should in part be addressed by biomarkers that detect the host response to microbiota, and the levels of microbial taxa and products eliciting the host response in susceptible individuals. Molecular analysis has revealed much evidence for microbial taxonomic membership and microbial products in association with IBD, but their utility as clinical biomarkers is still in its infancy. A rich area of progress has been the development and validation of host serologic microbial biomarkers, which have achieved a distinctive position in the diagnosis and prognosis in IBD, and as a template for defining other categories of microbial biomarkers in disease state and phenotype.

引用

页码：1265 / +

页数：13

共 119 条

[1]

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[2]

Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system [J].

Banati, M. ;

Csecsei, P. ;

Koszegi, E. ;

Nielsen, H. H. ;

Suto, G. ;

Bors, L. ;

Trauninger, A. ;

Csepany, T. ;

Rozsa, C. ;

Jakab, G. ;

Molnar, T. ;

Berthele, A. ;

Kalluri, S. R. ;

Berki, T. ;

Illes, Z. .

EUROPEAN JOURNAL OF NEUROLOGY, 2013, 20 (11) :1492-1495

[3]

Phylogenetic relationships of butyrate-producing bacteria from the human gut [J].

Barcenilla, A ;

Pryde, SE ;

Martin, JC ;

Duncan, SH ;

Stewart, CS ;

Henderson, C ;

Flint, HJ .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (04) :1654-1661

[4]

Inflammatory bowel diseases: from pathogenesis to laboratory testing [J].

Basso, Daniela ;

Zambon, Carlo-Federico ;

Plebani, Mario .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2014, 52 (04) :471-481

[5]

Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases? [J].

Berry, David ;

Reinisch, Walter .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2013, 27 (01) :47-58

[6]

Moving pictures of the human microbiome [J].

Caporaso, J. Gregory ;

Lauber, Christian L. ;

Costello, Elizabeth K. ;

Berg-Lyons, Donna ;

Gonzalez, Antonio ;

Stombaugh, Jesse ;

Knights, Dan ;

Gajer, Pawel ;

Ravel, Jacques ;

Fierer, Noah ;

Gordon, Jeffrey I. ;

Knight, Rob .

GENOME BIOLOGY, 2011, 12 (05)

[7]

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data [J].

Chen, Guo-Bo ;

Lee, Sang Hong ;

Brion, Marie-Jo A. ;

Montgomery, Grant W. ;

Wray, Naomi R. ;

Radford-Smith, Graham L. ;

Visscher, Peter M. .

HUMAN MOLECULAR GENETICS, 2014, 23 (17) :4710-4720

[8]

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters [J].

Cimermancic, Peter ;

Medema, Marnix H. ;

Claesen, Jan ;

Kurita, Kenji ;

Brown, Laura C. Wieland ;

Mavrommatis, Konstantinos ;

Pati, Amrita ;

Godfrey, Paul A. ;

Koehrsen, Michael ;

Clardy, Jon ;

Birren, Bruce W. ;

Takano, Eriko ;

Sali, Andrej ;

Linington, Roger G. ;

Fischbach, Michael A. .

CELL, 2014, 158 (02) :412-421

[9]

Cohavy O, 1999, INFECT IMMUN, V67, P6510

[10]

ASCA IgG and CBir Antibodies Are Associated with the Development of Crohn's Disease and Fistulae Following Ileal Pouch-Anal Anastomosis [J].

Coukos, Jennifer A. ;

Howard, Lauren A. ;

Weinberg, Janice M. ;

Becker, James M. ;

Stucchi, Arthur F. ;

Farraye, Francis A. .

DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (06) :1544-1553

← 1 2 3 4 5 6 7 8 9 10 →