Quantification accuracy and partial volume effect in dependence of the attenuation correction of a state-of-the-art small animal PET scanner

被引：35

作者：

Mannheim, Julia G. ^{[1
]}

Judenhofer, Martin S. ^{[1
]}

Schmid, Andreas ^{[1
]}

Tillmanns, Julia ^{[2
]}

Stiller, Detlef ^{[2
]}

Sossi, Vesna ^{[3
]}

Pichler, Bernd J. ^{[1
]}

机构：

[1] Univ Tubingen, Werner Siemens Fdn, Lab Preclin Imaging & Imaging Technol, Dept Preclin Imaging & Radiopharm, Tubingen, Germany

[2] Boehringer Ingelheim Pharma GmBH & Co KG, Target Discovery Res, Ingelheim, Germany

[3] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2012年 / 57卷 / 12期

关键词：

D O I：

10.1088/0031-9155/57/12/3981

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Quantification accuracy and partial volume effect (PVE) of the Siemens Inveon PET scanner were evaluated. The influence of transmission source activities (40 and 160 MBq) on the quantification accuracy and the PVE were determined. Dynamic range, object size and PVE for different sphere sizes, contrast ratios and positions in the field of view (FOV) were evaluated. The acquired data were reconstructed using different algorithms and correction methods. The activity level of the transmission source and the total emission activity in the FOV strongly influenced the attenuation maps. Reconstruction algorithms, correction methods, object size and location within the FOV had a strong influence on the PVE in all configurations. All evaluated parameters potentially influence the quantification accuracy. Hence, all protocols should be kept constant during a study to allow a comparison between different scans.

引用

页码：3981 / 3993

页数：13

共 10 条

[1] Radioactive spheres without inactive wall for lesion simulation in PET [J].

Bazanez-Borgert, Marisa ;

Bundschuh, Ralph A. ;

Herz, Michael ;

Martinez, Maria-Jose ;

Schwalger, Markus ;

Ziegler, Sibylle I. .

ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK, 2008, 18 (01) :37-42

[2]

Cherry SR, 2004, PHYS MED BIOL, V49, pR13, DOI 10.1088/0031-9155/49/3/R01

[3] PET Imaging of Prostate Cancer Xenografts with a Highly Specific Antibody against the Prostate-Specific Membrane Antigen [J].

Elsaesser-Beile, Ursula ;

Reischl, Gerald ;

Wiehr, Stefan ;

Buehler, Patrick ;

Wolf, Philipp ;

Alt, Karen ;

Shively, John ;

Judenhofer, Martin S. ;

Machulla, Hans-Juergen ;

Pichler, Bernd J. .

JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (04) :606-611

[4] In vivo quantification of dopamine transporters in mice with unilateral 6-OHDA lesions using [11C]methylphenidate and PET [J].

Fischer, Kristina ;

Sossi, Vesna ;

von Ameln-Mayerhofer, Andreas ;

Reischl, Gerald ;

Pichler, Bernd J. .

NEUROIMAGE, 2012, 59 (03) :2413-2422

[5] Noninvasive Nuclear Imaging Enables the In Vivo Quantification of Striatal Dopamine Receptor Expression and Raclopride Affinity in Mice [J].

Fischer, Kristina ;

Sossi, Vesna ;

Schmid, Andreas ;

Thunemann, Martin ;

Maier, Florian C. ;

Judenhofer, Martin S. ;

Mannheim, Julia G. ;

Reischl, Gerald ;

Pichler, Bernd J. .

JOURNAL OF NUCLEAR MEDICINE, 2011, 52 (07) :1133-1141

[6] Effects of cold sphere walls in PET phantom measurements on the volume reproducing threshold [J].

Hofheinz, F. ;

Dittrich, S. ;

Poetzsch, C. ;

van den Hoff, J. .

PHYSICS IN MEDICINE AND BIOLOGY, 2010, 55 (04) :1099-1113

[7] NEMA NU 2-2007 performance measurements of the Siemens Inveon™ preclinical small animal PET system [J].

Kemp, Brad J. ;

Hruska, Carrie B. ;

McFarland, Aaron R. ;

Lenox, Mark W. ;

Lowe, Val J. .

PHYSICS IN MEDICINE AND BIOLOGY, 2009, 54 (08) :2359-2376

[8] Partial-volume effect in PET tumor imaging [J].

Soret, Marine ;

Bacharach, Stephen L. ;

Buvat, Irene .

JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (06) :932-945

[9] Spatial Resolution and Sensitivity of the Inveon Small-Animal PET Scanner [J].

Visser, Eric P. ;

Disselhorst, Jonathan A. ;

Brom, Maarten ;

Laverman, Peter ;

Gotthardt, Martin ;

Oyen, Wim J. G. ;

Boerman, Otto C. .

JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (01) :139-147

[10]

Watson C, 2008, NSS 08 IEEE NUCL SCI, P5493

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