An evaluation of antidepressants in rheumatic pain conditions

被引:54
作者
Rani, PU
Naidu, MUR
Prasad, VBN
Rao, TRK
Shobha, JC
机构
[1] NIZAMS INST MED SCI, DEPT CLIN PHARMACOL & THERAPEUT, HYDERABAD 500482, ANDHRA PRADESH, INDIA
[2] NIZAMS INST MED SCI, DEPT ORTHOPAED, HYDERABAD 500482, ANDHRA PRADESH, INDIA
关键词
D O I
10.1097/00000539-199608000-00029
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
In a randomized, double-blind, parallel study, fluoxetine and amitriptyline were compared with placebo in the treatment of chronic rheumatic pain. A total of 59 patients were evaluated during 4 wk of treatment and received 20 mg fluoxetine, 25 mg amitriptyline, or placebo daily. Pain intensity, pain relief, vital variables, and global evaluation were used to assess efficacy. To evaluate safety variables, the incidence of side effects was noted. Both amitriptyline and fluoxetine significantly reduced pain intensity compared with placebo. Similarly, pain relief was greater with both amitriptyline and fluoxetine than with placebo. At the end of the fourth week, fluoxetine was superior in efficacy to amitriptyline. The incidence of adverse effects was significantly greater with amitriptyline; dryness of the mouth was the most predominant side effect. We conclude that fluoxetine is an effective analgesic with fewer side effects.
引用
收藏
页码:371 / 375
页数:5
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