SUMO and transcriptional regulation

被引：140

作者：

Girdwood, DWH ^{[1
]}

Tatham, MH ^{[1
]}

Hay, RT ^{[1
]}

机构：

[1] Univ St Andrews, Sch Biol, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 02期

关键词：

SUMO; E3; ligase; transcriptional repression; Ubc9; sub-nuclear targeting; ubiquitin-like protein; PML body;

D O I：

10.1016/j.semcdb.2003.12.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The small ubiquitin-like modifier (SUMO) is covalently attached to lysine residues in target proteins and in doing so changes the properties of the modified protein. Here we examine the role of SUMO modification in transcriptional regulation. SUMO addition to components of the transcriptional apparatus does not have a common consequence as it can both activate and repress transcription. In most cases, however, SUMO modification of transcription factors leads to repression and various models to explain this, ranging from retention in nuclear bodies to recruitment of histone deacetylases are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：201 / 210

页数：10

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