Predictable trends in protein noise

被引：6

作者：

Baetz, Kristin ^{[1
]}

Kaern, Mads ^{[1
]}

机构：

[1] Univ Ottawa, Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

来源：

NATURE GENETICS | 2006年 / 38卷 / 06期

关键词：

D O I：

10.1038/ng0606-610

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The process of gene expression is inherently stochastic and leads to differences in protein abundance from one cell to another. A new study shows that this protein noise is unexpectedly predictable, providing important new insights into the properties and origins of variability in gene expression.

引用

页码：610 / 611

页数：2

共 10 条

[1] Noise in protein expression scales with natural protein abundance [J].

Bar-Even, Arren ;

Paulsson, Johan ;

Maheshri, Narendra ;

Carmi, Miri ;

O'Shea, Erin ;

Pilpel, Yitzhak ;

Barkai, Naama .

NATURE GENETICS, 2006, 38 (06) :636-643

[2] Contributions of low molecule number and chromosomal positioning to stochastic gene expression [J].

Becskei, A ;

Kaufmann, BB ;

van Oudenaarden, A .

NATURE GENETICS, 2005, 37 (09) :937-944

[3] Noise in eukaryotic gene expression [J].

Blake, WJ ;

Kærn, M ;

Cantor, CR ;

Collins, JJ .

NATURE, 2003, 422 (6932) :633-637

[4] Regulated cell-to-cell variation in a cell-fate decision system [J].

Colman-Lerner, A ;

Gordon, A ;

Serra, E ;

Chin, T ;

Resnekov, O ;

Endy, D ;

Pesce, CG ;

Brent, R .

NATURE, 2005, 437 (7059) :699-706

[5] Noise minimization in eukaryotic gene expression [J].

Fraser, HB ;

Hirsh, AE ;

Giaever, G ;

Kumm, J ;

Eisen, MB .

PLOS BIOLOGY, 2004, 2 (06) :834-838

[6] Stochasticity in gene expression:: From theories to phenotypes [J].

Kærn, M ;

Elston, TC ;

Blake, WJ ;

Collins, JJ .

NATURE REVIEWS GENETICS, 2005, 6 (06) :451-464

[7] Control, exploitation and tolerance of intracellular noise [J].

Rao, CV ;

Wolf, DM ;

Arkin, AP .

NATURE, 2002, 420 (6912) :231-237

[8] Noise in gene expression: Origins, consequences, and control [J].

Raser, JM ;

O'Shea, EK .

SCIENCE, 2005, 309 (5743) :2010-2013

[9] Control of stochasticity in eukaryotic gene expression [J].

Raser, JM ;

O'Shea, EK .

SCIENCE, 2004, 304 (5678) :1811-1814

[10] Origins of extrinsic variability in eukaryotic gene expression [J].

Volfson, D ;

Marciniak, J ;

Blake, WJ ;

Ostroff, N ;

Tsimring, LS ;

Hasty, J .

NATURE, 2006, 439 (7078) :861-864

← 1 →